.... at least in mice
As a coffee-drinker I would be more encouraged by this, except that my mother-in-law was mad as a box of frogs and she loved her coffee.
Mad as a box of frogs... such a poetic expression.
I love coffee so it would be fun if it were proved to be virtuous to drink it.
But Merry, if she hadn't drunk so much coffee she might have been as mad as two boxes of frogs.

How many frogs do you get in a box?
Here's one that's thinking outside the box. Found him on the window a few nights ago. [Think he might have been searching for a tall cup of java at a Starbuck's...]
It's a tree frog of some sort, but hard to identify by his belly.
what a wonderful picture!